Higgenbotham wrote: ↑Mon Dec 02, 2024 10:14 pmThe stock market to me is reminiscent of the grind higher 5 years ago before covid hit.


Higgenbotham wrote: ↑Mon Dec 02, 2024 10:14 pmThe stock market to me is reminiscent of the grind higher 5 years ago before covid hit.
ROTTERDAM, THE NETHERLANDS—Locked up in the bowels of the medical faculty building here and accessible to only a handful of scientists lies a man-made flu virus that could change world history if it were ever set free.
The virus is an H5N1 avian influenza strain that has been genetically altered and is now easily transmissible between ferrets, the animals that most closely mimic the human response to flu. Scientists believe it's likely that the pathogen, if it emerged in nature or were released, would trigger an influenza pandemic, quite possibly with many millions of deaths.
In a 17th floor office in the same building, virologist Ron Fouchier of Erasmus Medical Center calmly explains why his team created what he says is "probably one of the most dangerous viruses you can make"—and why he wants to publish a paper describing how they did it. Fouchier is also bracing for a media storm. After he talked to ScienceInsider yesterday, he had an appointment with an institutional press officer to chart a communication strategy.
Fouchier's paper is one of two studies that have triggered an intense debate about the limits of scientific freedom and that could portend changes in the way U.S. researchers handle so-called dual-use research: studies that have a potential public health benefit but could also be useful for nefarious purposes like biowarfare or bioterrorism.
The other study—also on H5N1, and with comparable results—was done by a team led by virologist Yoshihiro Kawaoka at the University of Wisconsin, Madison, and the University of Tokyo, several scientists told ScienceInsider. (Kawaoka did not respond to interview requests.) Both studies have been submitted for publication, and both are currently under review by the U.S. National Science Advisory Board for Biosecurity (NSABB), which on a few previous occasions has been asked by scientists or journals to review papers that caused worries.
https://www.science.org/content/article ... lu-studiesThe research by the Kawaoka and Fouchier teams set out to answer a question that has long puzzled scientists: Does H5N1, which rarely causes human disease, have the potential to trigger a pandemic? The virus has decimated poultry flocks on three continents but has caused fewer than 600 known cases of flu in humans since it emerged in Asia in 1997, although those rare human cases are often fatal. Because the virus spreads very inefficiently between humans it has been unable to set off a chain reaction and circle the globe.
Some scientists think the virus is probably unable to trigger a pandemic, because adapting to a human host would likely make it unable to reproduce. Some also believe the virus would need to reshuffle its genes with a human strain, a process called reassortment, that some believe is most likely to occur in pigs, which host both human and avian strains. Based on past experience, some scientists have also argued that flu pandemics can only be caused by H1, H2, and H3 viruses, which have been replaced by each other in the human population every so many decades—but not by H5.
Fouchier says his study shows all of that to be wrong.
Although he declined to discuss details of the research because the paper is still under review, Fouchier confirmed the details given in news stories in New Scientist and Scientific American about a September meeting in Malta where he first presented the study. Those stories describe how Fouchier initially tried to make the virus more transmissible by making specific changes to its genome, using a process called reverse genetics; when that failed, he passed the virus from one ferret to another multiple times, a low-tech and time-honored method of making a pathogen adapt to a new host.
After 10 generations, the virus had become "airborne": Healthy ferrets became infected simply by being housed in a cage next to a sick one. The airborne strain had five mutations in two genes, each of which have already been found in nature, Fouchier says; just never all at once in the same strain.
Ferrets aren't humans, but in studies to date, any influenza strain that has been able to pass among ferrets has also been transmissible among humans, and vice versa, says Fouchier: "That could be different this time, but I wouldn't bet any money on it."
The specter of an H5N1 pandemic keeps flu scientists up at night because of the virus's power to kill. Of the known cases so far, more than half were fatal. The real case-fatality rate is probably lower because an unknown number of milder cases are never diagnosed and reported, but scientists agree that the virus is vicious. Based on Fouchier's talk in Malta, New Scientist reported that the strain created by the Rotterdam team is just as lethal to ferrets as the original one.
Dr. Yoshihiro Kawaoka of the University of Wisconsin-Madison and the University of Tokyo said in a commentary published online by Nature magazine that his team’s virus had infected ferrets through the air, but that it did not kill any of them. Ferrets catch flu just as humans do. Also, he said, “Current vaccines and antiviral compounds are effective against it.”
By contrast, a virus created by Ron Fouchier of Erasmus Medical Center in the Netherlands had both the high lethality of the H5N1 avian flu and the ability to transmit easily among ferrets, touching off fears that his virus could be devastating in people.
Some scientists believe that Dr. Fouchier created what is potentially the most lethal virus in history — a flu that would transmit through a sneeze and kill more than 50 percent of those who caught it. That has led to calls for restrictions. Some — including the editorial board of The New York Times — have argued that the virus stocks should be destroyed; others want the virus restricted to a small number of laboratories with the highest biosecurity levels.
Some scientists, including Dr. Fouchier, argue that the fear of his virus is exaggerated. What works in ferrets does not always work in humans, they argue, and the true lethality of avian H5N1 is unknown because there have been fewer than 600 confirmed human cases and many milder ones might exist.
https://forum.chasedream.com/thread-648811-1-1.htmlAfter reading Dr. Kawaoka’s commentary, Dr. Fouchier said it appeared that Dr. Kawaoka’s virus was less lethal than the one he created, although he reiterated that he did not think what he had created was as dangerous as it had been portrayed.
https://www.gurufocus.com/news/2621818/ ... t-concernsLeo KoGuan, a major individual shareholder of Tesla (TSLA, Financial), announced a reduction in his holdings of the automaker due to concerns over potential market sell-offs. He is reallocating some of the proceeds into U.S. government bonds, specifically 3-month Treasury bills. KoGuan cited the need to hedge his portfolio against a possible market crash reminiscent of 1929, driven by massive government debt and fiscal deficits.
This move marks a significant shift for KoGuan, who had previously been a staunch supporter of Tesla and its CEO, Elon Musk. In 2021, during a market upswing, KoGuan had expressed ambitions to increase his Tesla holdings until his net worth reached at least $100 billion. As of May, KoGuan owned 27.7 million Tesla shares, representing about 0.9% of the company, contributing significantly to his $13.5 billion fortune.
https://x.com/KoguanLeo/status/1862781282138333666KoGuan Leo
@KoguanLeo
No longer all-in-Tesla, I am selling Tesla and accumulating 3-month Treasury Bills. Still holding Tesla for long term. I believe WW3 is here; 1929 type stock market crash is looming. Our $36+ trillions debts; $2 trillions budget deficits; and almost $1 trillion trade deficit. Hedging my portfolio.
Herbert Ong
@herbertong
Nov 23
Replying to @KoguanLeo
Hi Professor Koguan. Are you still holding TSLA? Current thinking on this?
2:50 AM · Nov 30, 2024
229.4K Views
https://www.marketwatch.com/story/j-d-v ... d-aa05d713J.D. Vance warns of deliberate ‘bond-market death spiral’ if Trump is elected
By Steve Goldstein
Last Updated: Sept. 23, 2024 at 10:09 a.m. ET
First Published: Sept. 23, 2024 at 8:55 a.m. ET
Sen. J.D. Vance of Ohio, the Republican vice presidential nominee, is worried about a “bond-market death spiral.”
Former President Donald Trump often warns about financial calamities that could ensue if rivals are elected. His running mate says there could be a problem if he is elected.
Speaking to the former Fox News personality Tucker Carlson, Sen. J.D. Vance, the Ohio Republican and the party’s vice presidential nominee, said one of his big worries is the bond market.
“The thing I really worry about on bond markets is, OK, we have $1.6 trillion to $2 trillion in debt every single year in this country getting added to the national debt. And the only thing that makes that serviceable is that interest rates are still pretty low,” said Vance.
“If interest rates go to 8%, and you’re spending way more to service the debt than you are on actual goods, services and infrastructure for your country, like that can become a huge spiral that could take down the finances of this country,” he said.
Vance said Wall Street could deliberately try to sink a Trump presidency.
“I really worry about the bond markets. Do the international investors, the people who are getting rich off globalization, the people who have gotten rich from shipping our manufacturing base to China, the people who have gotten rich from a lot of wars — do they try to take down the Trump presidency by spiking bond rates?” Vance wondered aloud to Carlson.
Why top internet sleuths say they won't help find the UnitedHealthcare CEO killer
NBC Universal
MELISSA CHAN
December 7, 2024 at 10:31 AM
Thompson’s targeted killing has sparked online praise from people angry over the state of U.S. health care. Tens of thousands of people have expressed support on social media for the killing or sympathized with it. Some even appeared to celebrate it.
https://www.aol.com/news/why-top-intern ... 07741.htmlStill, some of the most popular internet sleuths have sat out the investigation.
“We’re pretty apathetic towards that,” Savannah Sparks, who has 1.3 million followers on her TikTok account — where she tracks down and reveals the identities of people who do racist or seemingly criminal acts in viral videos — said about helping to identify the shooter. She added that, rather than sleuthing, her community has “concepts of thoughts and prayers. It’s, you know, claim denied on my prayers there,” referring to rote and unserious condolences.
Although Sparks, 34, has been tapped by law enforcement in the past to help train officers on how to find suspects online, according to emails seen by NBC News, she said this time she isn’t interested in helping police.
Sparks, who also works in health care as a lactation consultant and holds a doctorate of pharmacy, didn’t mince words when asked if her community was working to find the suspect in Thompson’s murder.
“Absolutely the f--- not,” she said.
Another popular TikTok sleuth, thatdaneshguy, who has 2 million followers on the platform, made a video that was critical of the health care industry, saying that he wouldn’t try to identify the killer. “I don’t have to encourage violence. I don’t have to condone violence by any means. But I also don’t have to help,” he said.
That attitude among some content creators comes amid amplified attention on frustrations with medical care in the U.S. in the wake of the killing.
A Gallup poll released Friday found that Americans believe health care quality is at a 24-year low. Those polled said health care coverage is even worse, with 54% saying it’s fair or poor.
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